PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY*** PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
 
MENU
     
   
   
   
   
   
   
   
   
   
 
 
 
REVISITING THE CONCEPT AND APPLICATION OF THE PHENOMENON OF
TADBIR (DETOXIFICATION)*


Aftab Saeed, Tasneem Qureshi and Uzma Shafi
Hamdard Institute of Advanced Studies & Research, Hamdard University, Karachi, Pakistan

 

ABSTRACT: Greco-Arab System of Medicine contains diverse factors from different cultures in terms of philosophy and materia medica developed technically well-organized procedures of processing for safety and eliminating toxicity from natural drugs for rational therapy. This pharmaceutically established phenomenon in its application may be referred as Tadbir. Commonly it may be denoted as purification, processing and detoxification. At one hand this art of reduction of toxic components in natural drugs bear reference to the renowned Masters of Un ani Medical Science like Al-Razi, Al- Majusi and Al-Zahrawi. On the other hand, the phenomenon of Tadbir comprising different methods of purification, processing and detoxification are indicated to have been assimilated into Greco-Arab System of Medicine as historically established Indian medical (Ayurvedic) factors commonly referred as Sadhana (purification) and Marana (killing) under the overall concept of Rasa sastra. In scientific understanding of Tadbir procedures are employed to make raw natural drugs (mostly with temperament of 3rd/4'h Order) of poisonous nature or with known toxicity free from such poisonous, side or unwanted effects. There is detectable physico-chemical change observed on the part of the raw material as a result of such procedures, and the relevant items become easily digestible, absorbable and assimilable. Added advantage of such procedures is that as an outcome relevant natural drugs become harmless for administration in prescribed dose, more potent in exhibiting pharmacological activity and may be stored for longer periods as compared to unprocessed natural materials. In overall composition of natural raw drugs, following such processing methods, decrease in potentially toxic bioactive ingredients occurs. For example lowering of Strychnine in Nux vomica, Morphine in Opium, Phenols and Bhilawanol in Semecarpus, a-Glycosidic Chrysophanol in Rhubarb species etc. In the light of above mentioned study, an attempt has been made in this paper to project the benefits of Greco-Arab and Indian approaches towards employing the methods of processing, purification and detoxification of natural drugs in order to derive more benefits from the otherwise potentially toxic drugs in raw (unprocessed) state. Work is underway at the Hamdard Institute of Advanced Studies & Research, Hamdard University Karachi.