PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY*** PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
 
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AN IN VITRO STUDY OF SELECTIVE CARDIOVASCULAR EFFECTS OF
1-[4”-METHYLPHENACYL]-4-ACETYL-4-PHENYLPIPERIDINIUM BROMIDE


Syed Intasar Husain Taqvi, Mohammad Tariq Aftab*2 and Zafar Saeed Saify3
1Department of Pharmacology, Faculty of Pharmacy,
Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
2Department of Pharmacology, Post Graduate Medical Insitute, Baqai Medical University, Karachi, Pakistan
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

 

ABSTRACT: Study of a newly synthesized piperidine compound (1-[4’-methylphenacyl]-4-phenylpiperidinium bromide) on isolated whole heart of male rabbit. guinea pig ileum and rabbit thoracic aorta were performed for cardiac activity and probable mode of action respectively. Lengendorff’s technique determined the direct effect on myocardium. Guinea pig ileum and Rabbit aortic rings were employed to delineate the mechanism of action. The test compound educed the rate and force of contraction markedly. The coronary flow was decreased moderately. The compound failed to induce any spasmogenic or agonistic response in guinea pig ileum. High K+-induced contraction in rabbit aorta was relaxed dose-dependently. The contractile effect of norepinephirine was inhibited completely. The test compound was found to be cardio-active, devoid of agonistic activity and non-specific calcium antagonist.

KEY WORDS: Chronotropic, Inotropic, Vasocnstricting, Calcium antagonists