PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY*** PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
 
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THE EFFECT OF SURFACTANT ON THE DISSOLUTION RATE OF IBUPROFEN TABLETS


Nighat Razvi, Saeed Ahmad Siddiqui and Lubna Ghazal Khan Department of
Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan

ABSTRACT: The present work was conducted on the effect of surfactant on the dissolution rate of ibuprofen tablets. The cationic (Cetyl Trimethyl bromide) and anionic (Sodium dodecyl sulphate) surfactant present in the dissolution media have remarkable effect on the dissolution rate of Ibuprofen. Maximum dissolution was obtained in the presence of anionic surfactant (Sodium dodecyl sulphate) at 0.5% concentration of deionized water whereas non-ionic (Tween-80) surfactant had little effect on the dissolution of Ibuprofen tablets.

KEY WORDS: Dissolution, Dissolution media, Sodium Dodecyl Sulphate, Cetyl Trimethyl Bromide, Tween-80, Dissolution rate.