PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY*** PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
 
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ROLE OF EGG ALBUMIN AS A BINDER AND DISSOLUTION RATE ENHANCER

Nudrat Fatima, S. Ayub AIi*, Shahnaz Ahmad and Husan Afroz Rizvi
Phal1llaceutical Research Centre, PCSIR Laboratories Complex, Karachi

ABSTRACT: In present investigation, the effect of egg albumin on the rate of dissolution of analgesic tablets has been studied. Three sets of binder containing egg albumin in different ratios were used to prepare laboratory scale formulations
and their dissolution behavior was studied. The best result was achieved from formulation having all the three binders (egg albumin, gelatin and corn starch) in 1:1:1 ratio. The results were then compared to the commercially available tablets.
The results obtained show that egg albumin can be 'utilized as a binder in wet granulations of poorly water soluble drugs to improve their dissolution rate.

KEY WORDS: Analgesics, Binder, Dissolution rate, Egg albumin, Mefenamic
acid.