PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
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RESULTS OF RAPID ANTI MICROBIAL SENSITIVITY AND TOXICITY TEST
OF THE EXTRACTS OF SWERTIA CHlRATA, SYMPLOCOS RACEMOSA AND
SOLANUM NIGRUM


MansoorAhmad" Mehjabeen2, Noorjahan2, Noor Muhammad Shah" Manzoor Ahmad3, Hyder Raza2, Saeed Khan4 and Asif Bin Rehman2
Research Institute of Pharmaceutical Sciences, Depm1ment of Pharmacognosy, and Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan 2Department of Pharmacolog Faculty of Pharmacy, University of
Karachi, Karachi-75270, Pakistan 3HEJ research Institute of Chemistry, University of Karachi, Karachi-75270,
Pakistan Liaquat National Hospital, Karachi, Pakistan

ABSTRACT: An evaluation of anti microbial and cytotoxic effects of the plants extracts of Solanum nigrum (two varieties i.e. black and red fruits), Swertia chirata, Symplocos racemosa used as a medicinal agent in the cure of different ailment. The cytotoxic tests were carried our on Artemia Salina (brine shrimp). The results showed that there was no positive lethality of any of the plant except the Solanum nigrum having black barrier/fruits (SNBS). LD50 i.e. 927.0293 j.lg/ml was
found in upper toxic concentration, 258008.100 and lower toxic concentration is 231.0767. The anti bacterial activity of crude extracts were studied in vitro on gram positive and gram negative bacteria E. coli, Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae while antifungal activity was foundona range of concentration between 20-700mg/disc of dry extract and fungal organisms, Candida albicans and Aspergillus niger. The crude extracts except SNBS were devoid of any toxicity on Artemia salina with in the range of antimicrobial concentration, suggesting that the action is selective on microorganism.