PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
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ANTIDIARRHEAL EFFECTS OF ROSEMARY OIL
(ROSEMARINUS OFFICINALIS)


Muhammad Ibrar 1, Mansoor Ahmad2, Mehjabeen3, Noor Jahan3
and Kamran Ahmad Chishti4 I Department of Pharmacy, University of Peshawar, Peshawar, Pakistan 2 Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan 3Department of Pharmacology,
Faculty of Pharmacy, Faculty of Pharmacy, University
of Karachi, Karachi-75270, Pakistan.
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Faculty o/Pharmacy, University of
Karachi, Karachi-75270, Pakistan

ABSTRACT: The aim of this study was to investigate the antidiarrheal effect of pure volatile oil from the leaves of Rosemarinus of jicinalis (RO). In vitro experiments were performed by using the small intestine (ileum, jejunum) of rabbit. The results showed the dose dependent relaxing activity of intestine, which was found maximum at the dose of 25 mg/ml. It is also found that the extract exhibited both muscarinic and histaminic receptor blocking effect in comparison with control and standard drugs. When the tissue activity was blocked by calcium blocker (Verapamil I flM) and atropine I x lOA M and then treated with RO in a dose of 20 mg/m'. It showed further decrease in the activity in a cumulative way. Similarly upon blocking the adrenergic and muscarinic receptor the inhibitory effect of drug was also observed. The purpose of this work is to study the beneficial use of this oil in OIT disorder specifically as an antidiarrhoeal agent. Inhibition of smooth muscle contraction through the muscarinic and histaminic receptor and antagonist effect of the test drug exhibited a useful effect in the intestinal disorder.