PAKISTAN SOCIETY OF PHARMACOGNOSY & NATURAL THERAPY
PAKISTAN SOCIETY OF PHYTOPHARMACOLOGY & THERAPEUTICS
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COMPARATIVE PHARMACOLOGICAL STUDY ON RED AND BLACK FRUITS
AND LEAVES OF THESE TWO PLANTS OF SOLANUM NIGRUM
(BLACK NIGHTSHADE)

Mehjabeent, Noor Jahant, Mansoor Ahmed2, Kamran Ahmad Chishte, Shaista Hamid4 and Asif Bin Rehmanl I
Department (of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi-75270, Pakistan 2Research Institute of Pharmaceutical Sciences, Department of Pharmacognosy and Faculty of Pharmacy, University of Karachi,
Karachi-75270. Pakistan
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University (of Karachi. Karachi-75270, Pakistan
Department 4Pharmaceutics, Faculty of Pharmacy, University of Karachi,
Karachi-75270, Pakistan

ABSTRACT: The comparative study on red and black fruits and leaves of two plants of Solanum nigrum (Solanaceae) were studied on isolated preparation of rabbit intestine. The crude extracts (CE) and their ethyl acetate, chloroform, butanol and Aqueous fractions were tested at different dosing range to compare the efficacy and potency of leaves and fruits of both plants. The CE results shows that black fruits have potent acetylcholine like activity. It is also found that comparatively black fruits are having grater activity than leaves from red fruits plants than leaves from black fruits plant than red fruits. The ethyl acetate fraction of both leaves and fruits show maximum dose dependent contraction in black fruits. Chloroform fraction has mixed contracting and relaxing effects. Butanol fraction of leaves of both plants and black fruits have spasmogenic and red fruits showed dose dependent spasmolytic effects. Aqueous fraction of leaves of black fruits plant shows dose dependent spasmolytic effects while leaves of red fruits plant have dose dependent spasmogenic effects, Red fruits have both type of activities while black fruits have only spasmogenic effect. The results were also compared with standard drugs (atropine and adrenaline, used in different concentrations) to confirm the activities.

KEY WORDS: Solanum nigrum, Black night shade/mako, Smooth muscles, Spasmolytic and Spasmogenic activity.